Promethazine is metabolized from the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites appearing from the urine.
Hyperexcitability and irregular actions have been reported in individuals adhering to one administration of promethazine HCl. Thing to consider should be supplied on the discontinuation of promethazine HCl also to the use of other medicines if these reactions happen.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other typical measures, once the acute manifestations are actually controlled.
Avoidance and control of nausea and vomiting related to specified sorts of anesthesia and surgical procedures.
Promethazine HCl Oral Resolution ought to be utilised with caution in individuals with bone-marrow depression. Leukopenia and agranulocytosis happen to be described, normally when Promethazine (Promethazine HCl) has long been Utilized in association with other regarded marrow-toxic agents.
Prolonged-phrase animal scientific tests have not been carried out to evaluate the carcinogenic opportunity of promethazine, nor are there other animal or human details concerning carginogenicity, mutagenicity, or impairment of fertility with this particular drug. Promethazine was nonmutagenic inside the Salmonella test technique of Ames.
The exact system of action of codeine and other opiates is just not recognised; even so, codeine is believed to act centrally within the cough Heart. In too much doses, codeine will depress respiration.
Because these reactions could be noted voluntarily from a inhabitants of unsure sizing, It isn't normally probable to reliably estimate their frequency or build a causal marriage to drug publicity.
sedation, relief of stress and anxiety, and manufacture of light snooze from which the individual might be simply aroused
Because of the potential for promethazine to reverse epinephrine’s vasopressor result, epinephrine shouldn't be utilized to treat hypotension connected to promethazine overdose.
Minimal facts counsel that usage of promethazine hydrochloride through labor and shipping and delivery does not have an appreciable impact on the period of labor or shipping and doesn't boost the threat of will need for intervention during the new child.
The diagnostic evaluation of clients using this type of syndrome is complex. In arriving at a diagnosis, it is necessary to establish conditions where the scientific presentation includes each really serious professional medical illness (e.
Enhanced stress inside your head (greater intracranial stress). check here Steer clear of the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Solution Should you have a head injuries or are already explained to you have changes in the tissue of your Mind (brain lesions) or improved stress in your head.
Promethazine is extensively dispersed in physique tissues. Promethazine has substantial protein binding with about 80 to ninety three% of promethazine sure to plasma proteins. Promethazine passes the blood Mind barrier along with the placental barrier.